The new Laboratory for Agnostic Biosignatures (LAB) is developing techniques to detect life in the universe that humans can’t conceive of. Funded over the next five years with nearly $7 million from the NASA Astrobiology Program, the LAB team includes biologists, chemists, computer scientists, mathematicians, and instrument engineers. Together, these scientific disciplines aim to define potential extraterrestrial biosignatures, or signs of life, by imagining beyond the molecular framework of the only life we know of here on Earth. The team is also designing tools for detecting these signatures and strategies for interpreting them. LAB’s unique detection techniques can be used on bodies that include Mars, Jupiter, and Saturn’s icy moons.